PR-619: non-selective, reversible inhibitor of Ubiquitin and Ubiquitin-like Isopeptidases

PR-619 is a cell permeable inhibitor of Ubiquitin and Ubiquitin-like isopeptidases through the inhibition of various deubiquitylases (5-20 µM range). Once treated with PR-619, cells display an accumulation of both Ubiquitin and SUMO-conjugated proteins.

Applications: Non-specific inhibition of Isopeptidases

Application note: PR-619, a novel small molecule reversible inhibitor of deubiquitylases (DUBs).

White paper: The inhibition of Ubiquitin and Ubiquitin-like Isopeptidases through the use of a cell permemable small molecule.


  • Cell permeable
  • Reversible DUB inhibitor for in vivo and in vitro studies in µM concentrations

Vinyl Methyl Ester (VME) and Aldehyde inhibitors

  Ubiquitin-VME hSUMO1-VME Ubiquitin-Aldehyde hSUMO1-Aldehyde
  NEDD8-VME hSUMO2-VME NEDD8-Aldehyde hSUMO2-Aldehyde
  ISG15-VME ySUMO-VME ISG15-Aldehyde  


Other useful inhibitors related to the Proteasome pathway are available